A Comparison of the Effects of Gama Sterilisation and Ethylen Oxide Sterilisation Over the Bio-Compatibility of Polymeric Biomaterials

Faik Türkmen 1 * , Uğur Yensel 1
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1 Selcuk University Meram Medical Faculty Orthopedics and Traumatology Department Konya,Turkey
* Corresponding Author
EUR J BASIC MED SCI, Volume 1, Issue 1, pp. 1-6. https://doi.org/10.21601/ejbms/9160
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ABSTRACT

Bio-materials have find a very large area of utilization in medicine. Bio- compatibility is one of the important characteristics of bio-materials. In vivo and in vitro protocols can be implemented in research on bio-compatibility. The present research was conducted for the purpose of comparing the effects of gamma sterilization and ethylene oxide sterilization on bio-compatibility of various polymeric bio-materials. In this research, we used the technique of implantation on animals, which is one of the in vivo protocols, and we investigated different histological parameters utilizing sterilization techniques. A total of 180 ultra-high molecular weight polyethylene (UHMWPE), silicone, teflon, delrin and carbon fiber materials, whose bio-compatibility should be investigated, were prepared in the size of 1x1 cm in equal numbers from each. 90 of the materials, were sterilised with the gamma sterilisation technique whereas the remaining 90 were sterilised using ethylene oxide gas. Then, these materials were implanted on rats using appropriate techniques and histological and microbiological studies were conducted. As a result, we did not isolate microorganisms in either sterilization technique in samples that were examined after sterilization and we observed that both techniques had similar effects in terms of sterilization. However, it was observed that the sterilization technique that was implemented had an effect on bio-compatibility and that gamma sterilization was more compatible than ethylene oxide in terms of bio-compatibility. In performing microbiological examination, microorganisms were not isolated in either sterilization method and a similar effect for sterilization was observed in this research.
Keywords: bio-materials, bio-compatible, gamma sterilization, ethylene oxide sterilization

CITATION

Türkmen F, Yensel U. A Comparison of the Effects of Gama Sterilisation and Ethylen Oxide Sterilisation Over the Bio-Compatibility of Polymeric Biomaterials. Eur J Basic Med Sci. 2011;1(1):1-6. https://doi.org/10.21601/ejbms/9160

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