Heat Shock Proteins and Cancer

Müfide Öncel 1 *
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1 Konya Numune Hastanesi Biyokimya Laboratuarı
* Corresponding Author
EUR J BASIC MED SCI, Volume 2, Issue 1, pp. 16-23. https://doi.org/10.21601/ejbms/9171
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ABSTRACT

Heat shock proteins are a group of proteins in all living cells. They are synthesized due to various environmental factors, not only against high-temperature. These proteins are preserved in all prokaryotes and eukaryotes. Heat shock proteins play in part many pathological conditions such as autoimmune diseases, infectious diseases, heart diseases and cancer. Their effects on cancer development are provided by suppression of anticancer mechanisms such as apoptosis, cellular aging, activated immune system and increased metastatic gene expression. The inhibitors of heat shock proteins have been involved in the treatment of cancer due to their targeting cancer specific proteins and inhibitions of autonomous growth.
Keywords: heat shock proteins, cancer, apoptosis, anticancer activity

CITATION

Öncel M. Heat Shock Proteins and Cancer. Eur J Basic Med Sci. 2012;2(1):16-23. https://doi.org/10.21601/ejbms/9171

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