Hepatoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Carbon Tetrachloride (CCI4) Induced Acute Hepatotoxicity in Rats

Süleyman Özen 1 * , Hayal Oral 2, Hanefi Özbek 3
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1 Yüzüncü Yıl University Medical School, Department of Pathology, Van, Turkey
2 Adana Government Hospital, Department of Pathology, Adana, Turkey
3 The Ministry of Health, Drug Agency, Ankara, Turkey
* Corresponding Author
EUR J BASIC MED SCI, Volume 1, Issue 1, pp. 7-12. https://doi.org/10.21601/ejbms/9161
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ABSTRACT

In this study, hepatoprotective activity of CAPE, which has antiinflammatory, anticancer, antiviral, and immunomodulatory effects, was investigated in the CCI4 induced liver injury model in rats. Twenty-one Sprague Dawley rats were divided into the three groups: Control (n=7), CCI4 (n=7), CCI4 + CAPE (n=7). The serum levels of AST, ALT, LDH, and bilirubin were measured on the first and last day (10 th day) in all experimental animals. Histopathological examinations were carried out in the rats sacrificed on the tenth day. For histopathological evaluation, livers of all rats were removed and processed for light microscopy. The levels of unconjugated bilirubin, AST, ALT, ALP in CCI4 group were markedly higher than those in the control group (p<0.01, p<0.01, p<0.001 and p<0.05 respectively). The values of these parameters in CAPE+CCI4 group were lower than those in CCI4 (p<0.01, p<0.05, p<0.05, p<0.001 respectively). Histopathological findings also corfirmed that CCI4 induced hepadic damage and support the wiev that CAPE has a hepatoprotective activity. The results of this study indicate that CAPE has a hepatoprotective action in acute liver injury.
Keywords: carbon tetrachloride (CCl4), acute hepatotoxicity, caffeic acid phenethyl ester (cape), rat

CITATION

Özen S, Oral H, Özbek H. Hepatoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Carbon Tetrachloride (CCI4) Induced Acute Hepatotoxicity in Rats. Eur J Basic Med Sci. 2011;1(1):7-12. https://doi.org/10.21601/ejbms/9161

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