Importance of Platelet Markers for Demonstrating the Presence of Inflammation in the Different Stages of Chronic Renal Diseases

Mehmet Koroglu 1 * , Nilgul Akalin 2, Hanise Ozkan 3, Ozlem Harmankaya 2
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1 Medical Park Medical School, Internal Medicine, Turkey
2 Bakirkoy Dr Sadi Konuk Training and Research Hospital, İnternal Medicine and Nephrology, Turkey
3 Bakirkoy Dr Sadi Konuk Training and Research Hospital, Internal Medicine, Turkey
* Corresponding Author
EUR J BASIC MED SCI, Volume 5, Issue 1, pp. 1-9. https://doi.org/10.15197/sabad.2.5.01
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ABSTRACT

There is no consensus about association between platelet markers and atherosclerosis in chronic renal diseases. In our study, we aimed to show the effects of platelet markers, in the patient with different stages of chronic renal diseases. Four groups as control, chronic renal diseases, hemodialysis and peritoneal dialysis groups were included; in the study. Venous blood samples were taken from all of the patients following a 12-hour fasting period and anemia and biochemical parameters were measured. Known as atherosclerotic risk factors the levels of C-reactive protein, HOMA-IR, C-peptide with platelet markers (mean platelet volum, plateletcrit, platelet distribution width) were measured and their’s correlations were evaluated. The values of C-reactive protein, HOMA-IR, C-peptide and mean platelet volum in the patient groups were found higher than in the control grup. The positive correlation was determined the between levels of mean platelet volum with C-reactive protein, HOMA-IR, C-peptide, in the patient groups. Plateletcrit levels of the cases in chronic renal disease group were found to be significantly higher than the cases in other groups. No different was shown to the values of platelet distribution width, between the patients with different stages of chronic renal disease. We found that mean platelet volume was increased in the patients with chronic kidney diseases and they might associated the increased risks of inflammation and atherosclerosis. It is possible to use platelet markers as a biomarker to estimate atherosclerosis risk; in chronic kidney diseases.
Keywords: chronic renal disease, dialysis, inflammation, platelet markers

CITATION

Koroglu M, Akalin N, Ozkan H, Harmankaya O. Importance of Platelet Markers for Demonstrating the Presence of Inflammation in the Different Stages of Chronic Renal Diseases. Eur J Basic Med Sci. 2015;5(1):1-9. https://doi.org/10.15197/sabad.2.5.01

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