Investigation of Serum Sialic Acid Levels and Correlation Between Inflammatory Markers in Patients with Fibromyalgia

Aysun Toker 1 * , Hümeyra Çiçekler 2, Fatma Hümeyra Yerlikaya 1, Sami Küçükşen 3, Adem Küçük 4
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1 Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya
2 Atatürk Devlet Hastanesi, Biyokimya Laboratuvarı, Zonguldak
3 Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Konya
4 Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Romatoloji Anabilim Dalı, Konya
* Corresponding Author
EUR J BASIC MED SCI, Volume 3, Issue 2, pp. 24-28. https://doi.org/10.21601/ejbms/9197
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ABSTRACT

Fibromyalgia is a chronic condition causing pain, stiffness, and tenderness of the muscles, tendons and joints. It is also characterized by restless sleep, tiredness, fatigue, anxiety, depression. It is assumed that pro- and anti-inflammatory cytokines play a role in the induction and maintenance of pain. Studies to investigate cytokine levels in patients with fibromyalgia include different results. Sialic acid is an acetylated derivative of neuraminic acid and it is attached to non reducing residues of carbonhydrate chains of glycoproteins and glycolipids. The etiology of fibromyalgia remains unknown. In this study, we have investigated serum sialic acid and CRP levels and erythrocyte sedimentation rate (ESR) in patients with fibromyalgia and the correlation between these parameters. Materials and methods: 52 patients with fibromyalgia and 32 healthy individuals were contributed in our study. The diagnosis of fibromyalgia was based on the classification criteria declared by American College of Rheumatology at 1990. Serum sialic acid levels were measured by Warren’s method. CRP and ESR measurements were performed using routine laboratory methods. Serum sialic acid and CRP levels and ESR were significantly higher in patients with fibromyalgia compared with the healthy controls. In addition, a positive correlation was found between serum sialic acid and CRP levels and ESR values. Although fibromyalgia is known as a non-inflammatory condition, increased serum sialic acid levels in fibromyalgia indicate that an inflammatory component may play role in the pathogenesis of fibromyalgia.
Keywords: fibromyalgia, sialic acid, inflammation

CITATION

Toker A, Çiçekler H, Yerlikaya FH, Küçükşen S, Küçük A. Investigation of Serum Sialic Acid Levels and Correlation Between Inflammatory Markers in Patients with Fibromyalgia. Eur J Basic Med Sci. 2013;3(2):24-8. https://doi.org/10.21601/ejbms/9197

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