The Effects of Dexmedetomidine and Propofol on the Antioxidant System

Haluk Dülger 1 * , Hediye Kelemençe 2, Uğur Göktaş 3, M. Ramazan Şekeroğlu 2, İsmail Katı 3, Serpil Özcan 2, Fatma Çorcu Baran 2
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1 Selçuk Üniversitesi Meram Tıp Fakültesi, Biyokimya Anabilim Dalı, Konya
2 Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Van
3 Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Van, Turkey
* Corresponding Author
EUR J BASIC MED SCI, Volume 1, Issue 1, pp. 21-27. https://doi.org/10.21601/ejbms/9163
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ABSTRACT

The effects of many intravenous drugs, which are used for sedation anesthesia, on free radicals are well known. Two of these drugs are propofol and dexmedetomidine. This study was designed to investigate the effects of dexmedetomidine and propofol on the oxidant and antioxidant systems. Subjects were divided into two groups. Propofol were given to the first group (n=19) and dexmedetomidine to the second group (n=13) for sedation. Blood pressure and heart rate were recorded and serum ALT (alanine aminotransferase), AST (aspartate aminotransferase), creatinine, BUN (blood urea nitrogen), MDA (malondialdehyde), catalase and GSH-Px (glutathione peroxidase) were measured before and 2 hours and 2 days after the drug administration. When propofol and dexmedetomidine groups were compared in terms of blood pressure, heart rate, serum AST, ALT, BUN and creatinin values no statistically significant difference was detected. In propofol group MDA values decreased significantly (p<0.05) and GSH-Px values increased significantly (p<0.01) both in early and late phases following cessation of drug infusion when compared to before infusion. In dexmedetomidine group serum MDA, catalase and GSH-Px values did not alter significantly following cessation drug infusion. Propofol was found effective inprevention of oxidative damage and thus decreased serum MDA values and increased GSH-Px levels. Similarly dexmedetomidine had antioxidant effects. However, we thought that more comprehensive work including larger population requires to verify this conclusion.
Keywords: oxidative stress, antioxidants, propofol, dexmedetomidine

CITATION

Dülger H, Kelemençe H, Göktaş U, Şekeroğlu MR, Katı İ, Özcan S, et al. The Effects of Dexmedetomidine and Propofol on the Antioxidant System. Eur J Basic Med Sci. 2011;1(1):21-7. https://doi.org/10.21601/ejbms/9163

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